the association between c424c/a polymorphism within the il-25 gene and multiple sclerosis

results the results showed that there was no statistical significant difference in distribution of genotype (aa, ac and cc) and allele (a and c) frequencies between ms patients and healthy controls (p = 0.901 and p = 0.728, respectively). conclusions in conclusion, it appears that the c424c/a polymorphism within the il-25 gene has no significant relationship with ms, and this polymorphism is probably not associated with ms complications, its onset and gender distribution. objectives the aim of this study was to investigate the c424c/a polymorphism within the il-25 gene in ms patients in comparison to healthy controls. patients and methods in this case-control study, 74 patients with ms and 75 healthy controls were selected. polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) was used in order to determine c424c/a polymorphism within the il-25 gene. background multiple sclerosis (ms) is a common autoimmune system disease which affects the central nervous system. it has been documented that interleukin-25 (il-25) plays key roles in suppressing th1 responses, which is increased during ms.